Zaltrap Approved for Advanced Colorectal Cancer

FRIDAY, Aug. 3 (HealthDay News) -- Zaltrap (ziv-afilbercept) has been approved by the U.S. Food and Drug Administration in combination with a FOLFIRI chemotherapy regimen for adults with advanced metastatic (spreading) colorectal cancer, the agency said Friday.

FOLFIRI stands for a regimen that includes folinic acid, fluorouracil and irinotecan. Zaltrap, among a class of drugs called angiogenesis inhibitors, restricts tumor growth by inhibiting their blood supply. The drug was approved for people whose tumors are resistant to or have progressed after oxaliplatin-based chemotherapy, the FDA said in a news release.

Colorectal cancer, the 4th-leading cause of cancer and cancer deaths in the United States, will be diagnosed in an estimated 143,460 Americans this year, and about 51,690 will die from it, the agency said.

In clinical testing, people who received the Zaltrap-FOLFIRI combination lived an average of 13.5 months, compared to 12 months with a combination of FOLFIRI and a placebo, the FDA said.

The most common side effects of the Zaltrap-FOLFIRI combination included decreased white blood cells, diarrhea, mouth ulcers, fatigue, high blood pressure, weight loss, loss of appetite, abdominal pain and headache.

Zaltrap is produced by Sanofi-Aventis, based in Bridgewater, N.J.

More information

To learn more about colorectal cancer, visit the U.S. National Cancer Institute.

Source: http://news.yahoo.com/zaltrap-approved-advanced-colorectal-cancer-180410748.html

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Imran Khan lost donation money in real estate gambling: Khawaja Asif

PML-N leader?s provid?e 'eviden?ce' of Imran Khan's invest?ment of donati?on money abroad.

ISLAMABAD:?Khawaja Asif, a senior leader of the Pakistan Muslim League ? Nawaz (PML-N), alleges that Pakistan Tehreek-i-Insaf (PTI) chief Imran Khan lost a huge amount of money which was donated to his social welfare hospital, Shaukat Khanum Memorial Cancer Hospital & Research Centre, in a real estate gamble.

Asif, accompanied by two other PML-N leaders, held a press conference in Islamabad on Wednesday and handed out hard copies of ?evidence? against Khan?s investments.

The leader said that a total of $4.5 million were invested abroad, which was ?in fact the money gained from sadqaat, fitrana and zakat? This was the money of the Pakistani nation which went abroad.?

?In British Virgin Islands, a shell company was first registered. That company transferred money into a company, HBG in Dubai, then HBG bought shares of Sugarland company worth $3 million. During 2009-2010, Sugarland declared losses and in the coming two years, it faced 64% losses. Here, the money of Shaukat Khanum invested by Imran Khan also faced a loss but it was not shown,? Asif said while referring to the documents he had distributed.

The leader mentioned the Double Shah scam and said that Double Shah would at least ask for investments and not for donations, and his business was more transparent than this one. ?Imran Khan doesn?t get tired of unleashing allegations against the entire world, but he should first look at himself too.?

Asif questioned Khan that if the investment was so safe and profitable, then why did he not put in his own money rather than that of Shaukat Khanum. ?This is not a scandal of the PTI, this was a play of Shaukat Khanum?s money? Shaukat Khanum has not published its balance sheets, the last one available is from 2010, which we have provided to you.

?Imran Khan should reply himself or someone from the trust should reply. Who knows what game Imran Khan is playing with the people?s money and where he?s investing the donations,? he added.

?Shaukat Khanum workers are Khan?s friends or family?

Asif also alleged that those working at Shaukat Khanum Memorial Hospital are either Khan?s friends or family members. ?Another important person is Imtiaz Haideri. He is a member of Imran Khan?s trust, is a chief executive in Dubai and a chief executive in British Virgin Islands too.?

?In this party (PTI), they are all real estate businessmen or are involved in collecting donations. There is this singer as well, who also collects donations. The whole leadership is involved in the real estate business, they are all gamblers,? said Asif adding that he is providing proof from Shaukat Khanum?s own papers.

?We are not speculating or assuming this. We have handed you all the balance sheets too on which all the investments are stated.?

?During a Public Accounts Committee meeting, I asked NAB without mentioning any name that if a social welfare organisation is involved in such gambling investment, does your law allow them to catch them. They told me yes, they would take action? When the time comes, we will also go to the court.?

?We know it hurts the credibility of leaders before the elections, but we are trying to show the real face (of Imran Khan) on how he is managing the donations,? Asif added.

?Imran Khan took some wrong decisions and the trust should not bear the losses. The loss should come on his personal balance sheet.?

Read PML-N?s fact sheet on Shaukat Khanum Memorial Hospital here.

Source: http://tribune.com.pk/story/415920/imran-khan-lost-donation-money-in-real-estate-gambling-khwaja-asif/

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Sale on O "Oprah Magazine" Taste of Home, and Harper's Bazaar ...

Below are a few sales going on right now at Best Deal Magazines! They have ?the coupon code to use to score the discounted price. Just click on the picture to go to the page to order!! Great magazine sales

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The 'Dangers' Of The Argentine Tango

The Argentine Tango is a nostalgic dance which originated on the streets of Buenos Aires towards the end of the 19th century. It has grown in popularity over the years amongst social dancers. The music is a lot more varied and modern than the conventional ballroom tango music with elements of blues and rock music, which is why at some dances the Argentine Tango alone is danced all evening.

The movements consist mainly of walks with the feet making close contact with the floor at all times. The follower normally walks with her legs outside of her partners. It is danced counterclockwise around the floor, and cutting across the middle of the floor is strongly frowned upon.

Argentine Tango is a bit different, a bit dangerous and a bit more exciting than the normal tango. The reason for this is that the woman must allow the man to utterly 'control her body.' It is danced in an embrace which can vary from wide at arms length to a very close chest on chest.

Apart from having to balance herself perfectly with his frame, she has to feel the slightest hint of him stepping forward, so that she can shoot her corresponding foot backwards and be ready for any sudden changes.

The lady can occasionally choose to decorate him with her foot or leg, but mostly she is his mirroring puppet. This I know won't suit a lot of strong-willed woman. It's like he is doing all the talking for once.

Some woman will struggle to come to terms with this imbalance, but this type of connection is very necessary to allow for the correct execution of the Argentine Tango.

With the right partner the Argengine Tango can be extremely sexy as well as strangely spiritual. The dancers have to give the audience the impression that they have been lovers for ages.

In Buenos Aires it is the custom to have milongas or gatherings where the Argentine Tango is the dance of the evening. There are however a few rules you need to follow if attending one of these Milongas.

Firstly you have to dance with a partner for at least three songs, even if he dances like a 'hefalump.' Woman are never allowed to ask the men to dance. Men tend to try and avoid rejection by simply looking at you and jerking their heads towards the dance floor if they want to dance with you.

Whatever way you choose, the Argentine Tango might just be the dance for you, and if you enjoy ballroom dancing, then you simply have to give it a whirl.

For more on dance related matters, please visit The Dancers Forum

Source: http://articles.submityourarticle.com/the-dangers-of-the-argentine-tango-285861

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Amazon Instant Video arrives on iPad in the U.S., brings tons of movie and TV fun

Amazon Instant Video is finally -- finally -- available for iPad in the U.S., and with it comes the entire movie and TV catalog. That catalog includes over 120,000 videos available for purchase or rent, thousands of which can be streamed for free if you're an Amazon Prime member. Here's the official blurb:

Watch thousands of titles available from Prime Instant Video at no additional cost with an Amazon Prime membership and over 120,000 videos available from the Amazon Instant Video store by installing the Amazon Instant Video app. Download purchased and rented videos from Your Video Library for offline viewing on airplanes, road trips, or any time a WiFi connection is unavailable. Keep track of movies and TV shows to watch later by adding them to Your Watchlist. A selection of top Prime Instant Video titles is included in the app, and you can visit Amazon to add other Prime titles to Your Watchlist. Start watching a video on an iPad and Whispersync technology automatically syncs your place between devices, allowing videos to be resumed from where you left off on a Kindle Fire, PS3, PC, Mac, or hundreds of models of connected TVs and Blu-ray players.

Thanks to Amazon's WhisperSync, the same thing that keeps all your Kindle books on the same page, you can start watching on iPad and keep watching right where you left off on Kindle Fire, PS3, Windows, Mac, and compatible TVs and entertainment boxes like Blu-Ray players. Or vice-versa.

Sadly, there's no iPhone or iPad version yet, and Amazon's content availability outside the U.S. remains pathetic. (Meanwhile Apple's making billions internationally -- go figure?). There's also no Apple TV version yet or even AirPlay support, though given Hulu Plus' recent move to the Apple TV, hopefully Amazon's appearance isn't too far behind.

Also, Phil Nickinson of Android Central says not all episodes of some shows, like West Wing, are currently available on iPad the way they are on Kindle Fire. Since Amazon reportedly doesn't even break even on Kindle Fire sales, and their business model depends on content sales, this might simply be an issue of them not getting their virtual shelves stocked fast enough for iPad.

Still, it is nice to see all these content deals line up before the rumored "fall product transitions".

If you load up Amazon Instant Video on your iPad, let me know how it works for you. How's the Amazon experience on iPad compared to Kindle Fire, and compared to Netflix on the iPad?

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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/OnSrwKuSspQ/story01.htm

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Let Reid Pour Some Sugar On That Threeway, Sept 24th, Baltimore ...

It?s a popular fantasy with twice the pleasure potential, but navigating a three-way romance (if only for one night) can be tricky.

Join world renowned sex and relationship educator Reid Mihalko for this fun-filled, two-hour workshop on Negotiating Successful Threesomes? (with live demonstrations!)?

Not only will you get a chance to ask questions, but we?ll cover:

• What are the best techniques to satisfy two lovers at once?
• Ways to overcome fears and concerns ? yours AND your partner?s!
• The most common threesome mistakes (and how to avoid them!)
• How to negotiate boundaries and safer sex protocols to make your next m?nage ? trois tr?s bien!

DATE: Mon, Sept 24th, 2012
TIME:?6:30-8:30pm
WHERE: Baltimore?s one and only Sugar!
927 West 36th Street (on the Avenue in Hampden), Baltimore, MD?21211 -?View Map
Questions? Call?410.467.2632
Cost: $25 - Buy tix in advance to guarantee your seat! Buy tickets?soon!

For more information? see www.sugartheshop.com

See Reid?at Woodhull?s Sexual Freedom Summit, too!

Whether you?ve had more threesomes than Jim Morrison or are just beginning to consider three-in-a-bed might be something you?d like to explore, this workshop will give you plenty of tools, tricks, perspectives and laughs to enhance your love life and strengthen your relationships!

Even if you would NEVER be interested in a 3-way, this fun-filled class will give you lots of ways to talk to your loved ones about the things you DO WANT in the bedroom ? no matter how tame or outrageous!

Bring your loved ones, bring your friends, and enjoy an educational and entertaining evening on how to successfully navigate one of the most common sexual fantasies: the threesome!

See Reid?at?Woodhull?s Sexual Freedom Summit, too!

ABOUT REID: Reid Mihalko of www.ReidAboutSex.com helps adults create more self-esteem, self-confidence and greater health in their relationships and sex lives, no matter what their self-expression of those happen to be.

From his rated-PG/PG-13 workshops (Cuddle Party, Speed-Flirting) to the rated-R (Iron Slut Sex Educator Showdown) to his explicit, NC-17 rated, Show-N-Tell sex education workshops (where audiences get to watch, take notes, and ask questions), Reid?s workshops have been attended by close to 40,000 individuals from myriad walks of life, orientations, relationship styles, countries and religions. Known for his charisma, wit and emphasis on integrity, Reid travels the country teaching, coaching, consulting and collaborating on fulfilling his mission: Create more self-esteem, self-confidence and health for adults in and out of the bedroom.

Reid has been a featured speaker at dozens of conferences on relationships and sexuality and is a sought-after presenter and teacher at colleges and sex positive stores across the country.

Reid has been a writer and producer on a number of films and television projects about sex and relationships, and appears regularly in the media. He has also appeared on the Emmy award-winning talk show Montel, Fox News, OWN?s Our America with Lisa Ling, Bravo?s Miss Advised,?VH1?s Scott Baio is 45 and Single, Showtime?s Penn & Teller?s Bulls**t!, Canada?s The Sex Files and SexTV, and the short-lived Life & Style, on NPR, Sirius? Maxim Radio and Cosmo Radio, and in Marie Claire, GQ, Details, People, Newsweek and The National Enquirer, as well as media across the globe in thirteen countries and at least seven languages.

Follow Reid twittering as @ReidAboutSex.

Tagged as: Baltimore, Negotiating Successful Threesomes, Sugar the Shop, Threesomes

Source: http://reidaboutsex.com/let-reid-pour-some-sugar-on-that-threeway-sept-24th-baltimore-md/

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Pulse ? Mass Shootings & Law Enforcement - KPLR 11

Posted on: 4:45 pm, July 31, 2012, by Staff Writer, updated on: 04:55pm, July 31, 2012

ST. LOUIS, MO (KPLR) ? This week?s edition of The Pulse of St. Louis is about mass shootings and how law enforcement and society respond to them. Saint Louis University Associate Professor of Sociology and Criminal Justice, Dr. Norman White and the Chief of?the Maryland Heights Police Department, Colonel Thomas O?Connor discussed the issue with FOX 2?s Charles Jaco and host, Shirley Washington. They also discussed the issue?of guns and crime in the city of St. Louis.

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Source: http://kplr11.com/2012/07/31/pulse-mass-shootings-law-enforcement/

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