Saturday, February 16, 2013

Gay marriage vote poses challenge for Illinois GOP

SPRINGFIELD, Ill. (AP) - Democrats say they have enough votes to approve gay marriage on the floor of the Illinois Senate.
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But Thursday's vote poses a challenge for Republicans.
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After suffering big losses at the polls last fall, GOP leaders in Illinois and nationwide said the party needs to be more inclusive and diverse.
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But after Illinois Republican Party Chairman Pat Brady publicly backed gay marriage during January's lame-duck legislative session, members of the more conservative wing of his party called for his ouster. Opponents also pledged to fund primary challenges to any Republican who voted in favor of the bill.
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The conflict comes as voters' feelings are shifting rapidly in favor of gay rights.
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If the Senate approves the measure, it will move to the House.

(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)

Source: http://www.wpsdlocal6.com/news/local/Gay-marriage-vote-poses-challenge-for-Illinois-GOP-191177941.html

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Friday, February 15, 2013

Hands on: Mophie Juice Pack Air vs. the new Juice Pack Helium for iPhone 5

When the iPhone 5 first came out, I had to choose between continuing to use my iPhone 4S with a Mophie Juice Pack Air, or get the new iPhone 5 without an integrated battery pack case. Thinking that I would not have to wait very long for Mophie to come out with a new case designed for the iPhone 5, I decided to go with the iPhone 5. Four months of following the drama surrounding Apple?s new Lightning adapter?ensued and last week?Mophie released a new battery pack for Apple?s latest iPhone. Now, I finally have the new Mophie Juice Pack Helium for the iPhone 5 that I plan to use day to day.

It looks great, but as I?ll explain, it may take a bit of time to get used to the new model.

Air to Helium Side by Side

With the Mophie Juice Pack Air for the iPhone 4S, my initial impressions were that it made the iPhone a little bulkier. The iPhone felt thicker. With the latest model, the Mophie Juice Pack Helium, the first impression I had was that my iPhone was longer, while I barely notice that the phone is any thicker at all. Getting my hand around the iPhone 5 was already a bit of a challenge because of the slightly larger screen, but now with the Mophie Juice Pack Helium, I find myself scootching my hand up and down the back of the case in order to reach and touch every point on the screen. Like trying to press the home and power buttons at the same time. Until I get more comfortable and find the best way to hold the iPhone in its new case, I may be using two hands more often than I like to perform basic operations.

Air to Helium Thickness

On the Mophie Juice Pack Air for the iPhone 4S, the top of the case fit around the headphone jack in a similar fashion to other cases. Most headphones would still be able to attach to the headphone jack, but some would require an adapter to fit with the case on. In extreme situations, I could slide off the top of the case to fully expose the headphone jack. In contrast, the Juice Pack Helium on the iPhone 5 blocks access to the headphone jack quite a bit more. This is due to the fact that Apple decided with the iPhone 5 to move the headphone jack from the top of the iPhone to the bottom. Thankfully Mophie included a small adapter cable with the Helium that can reach the headphone jack and attach your favorite headphones.

Helium Headphone Jack

Both versions for the iPhone 4S and the iPhone 5 come with a 1500 mAh battery, which Mophie claims will extend the battery life of the iPhone 5 by 80 percent. And despite some of the minor inconveniences regarding length and access to the headphone jack I will be using this as my every day case moving forward. Nothing is more annoying than running out of battery life. I really enjoyed my Mophie Juice Pack Air with my iPhone 4S and have been looking forward to getting my hands on the Helium case for my new iPhone 5.

Source: http://feedproxy.google.com/~r/OmMalik/~3/k4cCJLRoxpA/story01.htm

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Thursday, February 14, 2013

Identification of abnormal protein may help diagnose, treat ALS and frontotemporal dementia

Identification of abnormal protein may help diagnose, treat ALS and frontotemporal dementia

Wednesday, February 13, 2013

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective treatment. Researchers are beginning to recognize ALS and FTD as part of a spectrum disorder with overlapping symptoms. Now investigators reporting online February 12 in the Cell Press journal Neuron have discovered an abnormal protein that first forms as a result of genetic abnormalities and later builds up in the brains of many patients with either disease.

"In identifying the novel protein that abnormally accumulates in the brains of affected patients, we have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases," says senior author Dr. Leonard Petrucelli, Chair of Neuroscience at Mayo Clinic in Florida.

By analyzing brain tissue from patients with ALS or FTD, Dr. Petrucelli and his team discovered that the abnormal protein, which they call C9RANT, is generated as a result of repeat expansions of nucleotides in the noncoding region of the C9ORF72 gene. These expansions are the most common cause of ALS and FTD. "Simply put, an error in the highly regulated cellular process through which proteins are generated causes the abnormal production of C9RANT," explains Dr. Petrucelli.

The researchers discovered the protein C9RANT after creating a novel antibody to specifically detect it. The ability to detect C9RANT in individuals' cerebrospinal fluid may provide a valuable diagnostic and prognostic tool for identifying patients carrying the C9ORF72 repeat expansion and for then tracking the progression of the disease in these at-risk individuals.

"Although it remains to be shown whether C9RANT is causing the cell death or toxicity associated with disease symptoms, our discovery offers a potential target to prevent neuronal loss in patients carrying the C9ORF72 repeat expansion," says Dr. Petrucelli.

The concept that abnormal proteins accumulate and can be toxic to cells is not new. In fact, tau protein forms tangles in Alzheimer's disease and alpha-synuclein forms clumps in Parkinson's disease. Just as new therapies are being developed to break down the protein aggregates associated with these diseases, developing a therapeutic strategy to target C9RANT aggregates may also prove beneficial.

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Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 36 time(s).

Source: http://www.labspaces.net/126761/Identification_of_abnormal_protein_may_help_diagnose__treat_ALS_and_frontotemporal_dementia

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Struggling Creighton's NCAA hopes on tenterhooks

OMAHA, Neb. (AP) ? The Creighton team once pegged to make a deep postseason run suddenly is no lock to even make the NCAA tournament.

The Bluejays (20-6) have lost three straight and five of their last eight, and they fell out of the Top 25 this week after being ranked No. 12 a month ago.

Coach Greg McDermott said his players face the choice of wallowing in self-pity or dedicating themselves to regaining the form that earned wins in 17 of their first 18 games.

"The world doesn't care if you fail. They don't," McDermott said. "There's no time to feel sorry for yourself. We've got important games ahead, an important one Saturday at Evansville. We have to use all the energy we have to get ourselves back in a better frame of mind."

The 61-54 loss at Northern Iowa this week followed a 75-72 home loss to Illinois State and an embarrassing 76-57 defeat at Indiana State. Fortunately for Creighton, no one has run off with the Missouri Valley Conference race.

The Bluejays (9-5 MVC) are tied with Indiana State for second place, one game behind a Wichita State team that has won two straight after a three-game losing streak of its own. Indiana State has lost to eighth- and ninth-place Missouri State and Drake the past two weeks.

Creighton plays three of its last five on the road, including one at surging Saint Mary's next week. That game, plus the finale at home against Wichita State, could be huge for the Bluejays to enhance their position for an at-large bid if they don't win the Valley tournament.

"We have to keep our attitude and work through this," senior Grant Gibbs said. "We can't point fingers now. That's not going to help us. We've got to stick together."

Doug McDermott remains the NCAA's No. 2 scorer at 23 points a game, and he's averaged 20.8 over the past eight games. But he's disappeared when the Bluejays have needed him most.

Against Drake, McDermott started feeling ill at halftime and scored two of his 19 points in the second half. He finished with just eight points against Indiana State, but all came in the first half and he took only one shot in the second.

He didn't take another shot after missing a 3-pointer with 4:22 left in a close game against Illinois State. Northern Iowa committed to denying McDermott the ball in the second half and held him to three points after he scored 12 the first 20 minutes. He didn't score in the second half until he made a free throw with 1:24 left. His other two points came on a dunk just before the buzzer.

The Bluejays remain the nation's top-shooting team, at 51 percent overall and 42.3 percent on 3-pointers. But when opponents have clamped down on McDermott and Gregory Echenique in the post, their teammates haven't been able to convert consistently from the perimeter.

About 40 percent of Creighton's shots have come from behind the 3-point line, and the Bluejays are a combined 27.6 percent from that distance in the last five losses.

Jahenns Manigat, who made 44 percent of his 3s during the 17-1 start, has made 30 percent since. Ethan Wragge is shooting 32.4 percent on 3s after making 46 percent through 18 games. Gibbs, a primary ball-handler, has committed 28 turnovers the past eight games after coughing up the ball 26 times the first 18.

It doesn't help the Bluejays' cause that Missouri Valley appears a bit down this season. The league received two NCAA bids last season (Creighton, Wichita State) but might not get more than the one it had each year from 2008-11.

"It's a strange year, without question," Greg McDermott said. "It's proven out that anybody can beat anybody, and when you think you've got it figured out, you might as well start over. I think it's going to be an interesting ride the rest of the year."

Source: http://www.mysanantonio.com/sports/article/Struggling-Creighton-s-NCAA-hopes-on-tenterhooks-4279057.php

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French economic growth grounds to halt

(AP) ? New figures show French economic growth last year ground to a halt, with GDP contracting to a flat 0 percent.

The French government numbers Thursday show GDP was down from 1.7 percent in 2011.

Independent auditors for the government called on France earlier this week to get its finances in order, saying the country is spending too much money ? much of it on wasteful programs ? and not taking in enough money in taxes.

French Prime Minister Jean-Marc Ayrault late Tuesday acknowledged that France would miss ambitious budget targets intended to stabilize its economy and meet European requirements. France is the world's 5th largest economy and the second-largest in Europe after Germany.

"Growth in France, Europe and the world is weaker than expected," Ayrault said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-02-14-EU-France-Economy/id-609af7ff894245e5b162a3141bad91ce

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Wednesday, February 13, 2013

Treasury nominee Lew calls tax reform top priority

WASHINGTON (Reuters) - President Barack Obama's choice to be the next Treasury secretary said on Wednesday that revamping the tax code is "at the very top" of his priorities, and he offered some olive branches to Republicans to achieve that goal.

Tax reform took center stage at the Senate Finance Committee's confirmation hearing for Jack Lew, Obama's nominee to replace Timothy Geithner. Lew told lawmakers that Obama is committed to a long-sought tax code overhaul and said that lowering all tax rates is possible if tough choices are made.

"It is possible. If we roll up our sleeves and are willing to do the hard work, we can both get our fiscal house in order and work on the rate structure," Lew, who has served as Obama's chief of staff and budget director, told the panel.

Republican Senator John Thune of South Dakota presented Lew with huge stacks of paper that were copies of the tax proposal offered by the Treasury Department under Republican President Ronald Reagan in 1986, intended to contrast with the slim pamphlets on a tax rewrite offered by Obama.

Lew responded that the 1986 overhaul, in its final form, did not resemble that original plan after it was hashed out by lawmakers over many months in congressional hearings in conjunction with the Treasury Department.

Still, Thune said the White House must play a larger role.

"This is not going to get done unless there is leadership out of the White House," he said. "There are lots of constituency groups out there that are very committed to the current tax code."

Republicans, Obama and his fellow Democrats say they back a revamp of the tax code, but the odds of achieving that are clouded by constant fiscal fights and conflict over whether new revenue is needed.

"In clearing out the tax code and broadening the base, there is room to raise the revenue that we need," Lew said.

Senate Finance Committee Chairman Max Baucus, a Montana Democrat, and House Ways and Means Committee Chairman Dave Camp, a Michigan Republican, are working on parallel tax reform plans and have held hearings for more than a year.

Camp, who intends to propose legislation this year, created 11 bipartisan working groups this week to study different aspects of tax reform, including financial services and charitable giving, according to a committee source.

"It is a small step in the right direction," said a lobbyist for a trade group that backs a lower corporate tax rate. To have Democrats and Republicans "sitting down in the same room is progress."

The mantra of tax reformers is "lower the rate, broaden the base." The second part of that phrase involves politically painful choices.

"Broadening the base" means increasing the amount of income subject to taxation, which requires cutting tax breaks. Those tax breaks likely to be targeted include deductions for investment earnings, mortgage interest and charities, which are prized by industries and many individuals.

On the corporate side, it could mean curbing tax breaks for oil and gas companies and requiring companies to pay more taxes on offshore earnings.

Republicans pressed Lew on lowering the corporate tax rate, which is 35 percent - the highest among developed countries. Obama has backed trimming that top rate to 28 percent, while Lew said it would be challenging to get it down to the Republicans' goal of 25 percent.

Lew was also asked about moving to a "territorial" tax system favored by big business and Republicans, where most of corporate income earned offshore is exempt from U.S. taxes.

Under the current worldwide tax system, most income, wherever it is earned, is subject to U.S. tax, though a plethora of laws allow companies to defer or avoid taxes on these profits.

Lew reiterated Obama's call for a minimum tax on foreign profits, which the president revived on Tuesday in his State of the Union speech. But when asked if he was open to a more territorial-like system, Lew said, "there is room to work together."

(Additional reporting by David Lawder; Editing by Kevin Drawbaugh, Vicki Allen and Stacey Joyce)

Source: http://news.yahoo.com/obama-treasury-pick-lew-says-hard-lower-corporate-164232144--sector.html

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Analysis: Obama isn't in the mood for compromise

WASHINGTON (AP) ? President Barack Obama had a simple message for Republicans in Congress: Do it my way.

Forget about shutting down the government to force spending cuts, he told the GOP in Tuesday night's State of the Union address. Don't think about defaulting on the debt and, while you're at it, close tax loopholes.

Clearly, Obama wasn't in a mood to compromise.

The president's speech doubled down on his hard-charging inaugural address in promoting liberal Democratic policy ideas, without ceding any ground to Republicans in Congress.

And from Obama's point of view, why should he? The president is fresh off a convincing re-election victory and Republicans are soul-searching over their party's future, increasingly reluctant to put up a fight. The GOP leadership already flinched by giving in on the debt ceiling and tax hikes. Obama seems determined to see what else he can get out of them.

At a time when Republicans are insisting on spending cuts, Obama pushed more public spending on universal preschool, construction work on bridges and schools and a jobs program rebuilding vacant homes in rundown neighborhoods. He pushed for an increase in the minimum wage to $9 an hour, with future increases tied to the cost of living. And he continued to push in support of left-leaning social issues including gun control, immigration reform, climate change and advancing equal rights for gays.

These were issues he didn't prioritize in his first term as he grappled with two wars and a recession ? and faced a re-election bid in which he needed to campaign for America's middle. But fresh off his convincing victory, unburdened by the prospect of another campaign, he has a rare and fleeting moment to push a second-term agenda that could shape his legacy.

The risk is he will alienate Republicans and accelerate gridlock. But Obama warned that voters won't look kindly on a stalemate.

"The American people don't expect government to solve every problem," he argued. "They don't expect those of us in this chamber to agree on every issue. But they do expect us to put the nation's interests before party. They do expect us to forge reasonable compromise where we can. For they know that America moves forward only when we do so together and that the responsibility of improving this union remains the task of us all."

Obama ridiculed Republican calls for cuts to spending on things like education, job training and Medicare and Social Security benefits to reduce the deficit. "Deficit reduction alone is not an economic plan," Obama said.

"Let's set party interests aside and work to pass a budget that replaces reckless cuts with smart savings and wise investments in our future. And let's do it without the brinksmanship that stresses consumers and scares off investors. The greatest nation on earth cannot keep conducting its business by drifting from one manufactured crisis to the next," Obama said to a sustained standing ovation from Democrats in the chamber while Republicans sat silent.

Obama did say he was "open to additional reforms from both parties" on Medicare, as long as they don't jeopardize Americans' retirement security. It was his one notable invitation to entertain Republican ideas, without making any promises or offering any specifics.

In the Republican response to Obama's address, Sen. Marco Rubio of Florida said the president has a habit of "falsely attacking" the motives of anyone who opposes his agenda. Rubio said Obama's "favorite attack" is to accuse Republicans of caring only about the rich, but tax increases and deficit spending hurt the middle class.

"Mr. President," Rubio responded, "I don't oppose your plans because I want to protect the rich. I oppose your plans because I want to protect my neighbors."

For now, Americans are far happier with Obama's leadership than they are with Congress. A recent Associated Press-GfK poll found that 54 percent of registered voters approve of the job Obama is doing, compared with just 17 percent for Congress.

But that isn't preventing Republicans from digging in their heels. House Speaker John Boehner told television correspondents and anchors Tuesday that immigration is about the only item on Obama's list that has a chance of passing this year. He said the president is more interested in getting a Democratic majority in both chambers next year and he doesn't believe Obama "has the guts" to take on liberals in his party over spending cuts.

Obama recognized that the divided Congress may not fall in line behind all his priorities, specifically mentioning climate change, but said he'd move forward with or without their support. "If Congress won't act soon to protect future generations, I will," Obama said. "I will direct my Cabinet to come up with executive actions we can take, now and in the future, to reduce pollution, prepare our communities for the consequences of climate change and speed the transition to more sustainable sources of energy."

The White House is acutely aware that Obama must act fast if he wants to be a transformational leader. The president has maybe a year before electoral politics tends to accelerate the already nasty gridlock between the White House and Republican lawmakers.

That's because come next year, members of Congress will be focused on their own campaigns for the midterm election. Then attention focuses on the race to succeed Obama with the primary campaign taking shape in 2015.

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EDITOR'S NOTE ? Nedra Pickler covers the White House for The Associated Press.

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Follow Nedra Pickler on Twitter at https://twitter.com/nedrapickler

An AP News Analysis

Source: http://news.yahoo.com/analysis-obama-isnt-mood-compromise-033556781--politics.html

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